Aklief Vs Tretinoin: Which Topical Retinoid Is The Best For You?

Tretinoin Is Old News!
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Acne can be a frustrating and painful skin condition that affects millions of people worldwide. Fortunately, there are several effective treatments available, including topical retinoids like Aklief and tretinoin. While both medications work by unclogging pores and reducing inflammation, Aklief has several advantages over tretinoin. So here’s why Aklief is the better option for acne treatment.

What Is Aklief?

Aklief is a topical medication that contains trifarotene, a new type of retinoid that specifically targets the receptors in the skin responsible for acne formation. It is the first and only topical retinoid approved for the treatment of acne vulgaris in over a decade. Aklief is available in the form of a cream and is applied once a day to the affected areas of the skin.

Also Read: What Is Linoleic Acid And How Does It Help Oily And Acne-Prone Skin?

What Is Tretinoin?

Tretinoin is a topical retinoid that has been used for decades to treat acne, wrinkles, and other skin conditions. It works by speeding up the skin cell turnover rate, which helps unclog pores and reduce inflammation. Tretinoin is available in several forms, including creams, gels, and lotions, and is applied once a day to the affected areas of the skin.

Why Aklief Is Better Than Tretinoin?

1. More Effective At Targeting Acne-causing Receptors

Aklief contains trifarotene, which specifically targets the receptors in the skin responsible for acne formation. This makes it more effective at treating acne than tretinoin, which targets a broader range of receptors in the skin. Studies have shown that Aklief can significantly reduce acne lesions in as little as four weeks, while tretinoin may take up to three months to show results.

2. Fewer Irritating Side Effects

One of the most common side effects of topical retinoids is skin irritation, including redness, dryness, and peeling. Aklief has been shown to cause fewer side effects than tretinoin, especially in terms of skin dryness and irritation. This is because trifarotene is more selective in its targeting of the skin receptors, which means it has a lower risk of irritating the surrounding skin.

3. More Convenient And Easier To Use

It is applied once a day, which is more convenient and easier to remember than tretinoin, which is typically applied every other day or every three days. This means that Aklief is less likely to be forgotten or used inconsistently, which can reduce its effectiveness.

Also Read: The Best AM And PM Skincare Routine For Acne-Prone Skin In Summer

4. Better For Sensitive Skin

It is less irritating to the skin than tretinoin, which makes it a better option for people with sensitive skin. This is because Aklief specifically targets the acne-causing receptors in the skin, while tretinoin targets a broader range of receptors, which can irritate the skin.


Overall, Aklief is a better option for those looking to effectively treat their acne without experiencing harsh side effects or needing to commit to a strict application schedule.

Disclaimer: Information provided is for educational purposes only and not a substitute for professional medical advice. Always consult a qualified dermatologist for any medical concerns.

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Sakshi Singh

She’s a skincare junkie, a fashion fiend, and a creative tornado in one package. Off-duty, either she is shopping or baking up yum!

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